Modification of DNA by chloroethylnitrosoureas.
نویسندگان
چکیده
منابع مشابه
Effect of 06-Methylguanine on DNA Interstrand Cross-Link Formation by Chloroethylnitrosoureas and Z-ChloroethyKmethylsulfonyOmethanesulfonate1
Exposure of III29 cells in culture to O'-methylguanine is known to result in a reduction in O'-alkylguanine-DNA alkyltransferase (AGT) activity and an enhancement of sensitivity to the cytotoxic effects of chloroethylating agents. Since cytotoxicity of these agents may be me diated by the formation of interstrand cross-links, alkaline elution analy sis was performed on HT29 cells treated with l...
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Interstrand DNA cross-linking is essential for the antitumor activity of Chloroethylnitrosoureas (CENUs). The critical cross-links have been proposed to involve a rapid O'-guanine chloroethylation on one DNA strand, followed by a rearrangement of the O6-(2-chloroethyl)guanine and slow alkylation of the second DNA strand. In view of the relative intracellular abundance of glutathione (GSH) and n...
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Interstrand DNA cross-linking is essential for the antitumor activity of chloroethylnitrosoureas (CENUs). The critical cross-links have been proposed to involve a rapid O6-guanine chloroethylation on one DNA strand, followed by a rearrangement of the O6-(2-chloroethyl)guanine and slow alkylation of the second DNA strand. In view of the relative intracellular abundance of glutathione (GSH) and n...
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Small DNA fragments have been used to modify endogenous genomic DNA in both human and mouse cells. This strategy for sequence-specific modification or genomic editing, known as small-fragment homologous replacement (SFHR), has yet to be characterized in terms of its underlying mechanisms. Genotypic and phenotypic analyses following SFHR have shown specific modification of disease-causing geneti...
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ژورنال
عنوان ژورنال: The Japanese Journal of Veterinary Science
سال: 1990
ISSN: 0021-5295,1881-1442
DOI: 10.1292/jvms1939.52.443